ENHANCES FIRMNESS & RADIANCE
Polynucleotides
Polynucleotides are an advanced injectable treatment offered at Beautiiful, designed to restore skin firmness, elasticity, and hydration while enhancing overall skin tone. This innovative bio-stimulating treatment is based on polynucleotide technology, a naturally derived molecule known for supporting the skin’s regenerative functions and addressing signs of ageing, uneven tone, and dehydration.
Polynucleotides work at a cellular level to encourage skin renewal and rejuvenation. By penetrating deep within the skin, they help neutralise oxidative stress and free radicals
— key contributors to premature ageing. The treatment can assist in improving the appearance of fine lines, pigmentation, scarring, and dehydration, while also promoting collagen synthesis to support smoother, firmer, and more radiant skin.
Widely recognised in regenerative medicine, polynucleotides contain naturally occurring compounds that stimulate the body’s own repair and healing mechanisms.
In aesthetic applications, when injected into the skin, they activate fibroblast cells — the specialised cells responsible for producing collagen and maintaining skin structure. This stimulation encourages the natural generation of collagen and elastin, helping the skin appear firmer, brighter, and more resilient.
Polynucleotides may also benefit uneven complexions and scarring, as their wound-healing properties help to support tissue repair. Additionally, the molecules bind with water, resulting in deep, long-lasting hydration and improved skin softness.
Unlike dermal fillers, which remain in the tissue until they gradually break down, polynucleotides work by triggering the skin’s own regenerative response and are naturally metabolised once their restorative effects have been activated.
TREATMENT PRICES
Polynucleotides Prices
Polynucleotides – £250 per area, per session (eyes, mid-face, lower face)
Treatment Plan:
For best results, a series of three treatments is performed at 2–3 week intervals. To sustain the improvements in skin quality, a maintenance session every six months is recommended.
Before and After
Polynucleotides Transformation
Testimonial
I had polynucleotides with Nadine for my under-eye area, and the results have been amazing. The skin looks smoother, more refreshed, and far less tired. Nadine made me feel completely comfortable throughout. She’s so gentle, professional, and reassuring. I’m really pleased with the whole experience.
Polynucleotides
Frequently Asked Questions
How do Polynucleotides work?
Polynucleotides, often referred to as PN or PDRN, are an injectable regenerative and skin-boosting treatment that has recently become a favourite in aesthetic medicine. Although widely known today for their skin-rejuvenating effects, they have actually been used in medical treatments since the 1980s, particularly for supporting tissue repair and joint health.
Composed of long chains of nucleotides — the essential building blocks of DNA and RNA — polynucleotides are typically sourced from purified and sterilised salmon or trout DNA. Their exceptional biocompatibility makes them safe for human use. When injected into the skin, polynucleotides deliver intense hydration and stimulate long-term bio-remodelling, helping to restore skin quality from within.
When will I see results?
Visible improvements are often noticed within 2 to 4 weeks after treatment, with the skin continuing to improve as it regenerates. The most noticeable results generally appear around three months after completing the full course.
A recommended treatment plan usually includes three sessions spaced 2–3 weeks apart, followed by a maintenance session every six months to help preserve results and keep the skin looking its best.
What are the benefits of Polynucleotides?
Polynucleotides offer multiple benefits for the skin, making them a versatile choice for rejuvenation. They help to:
- Improve skin texture, tone, and elasticity
- Reduce the appearance of fine lines and wrinkles
- Provide deep hydration for a dewy, refreshed complexion
- Encourage fibroblast activity and collagen production
- Support the skin’s natural healing and regenerative processes
- Help calm inflammation and reduce redness or swelling
Like hyaluronic acid-based skin boosters, polynucleotides enhance hydration and create a soft, glowing finish. However, they go a step further — actively stimulating tissue repair, regulating pigmentation (melanogenesis), reducing inflammation, and promoting skin renewal at the cellular level.
Because they work by encouraging your own cells to regenerate, results develop gradually as the skin’s natural repair cycle progresses. Factors such as age, diet, lifestyle, and skin quality can influence how quickly improvements become visible, but most individuals notice progressive enhancement in smoothness, firmness, and radiance.
What happens during the treatment?
Before the procedure begins, a topical numbing agent may be applied to ensure comfort. In a sterile and controlled setting, the polynucleotide solution is then carefully injected into the deep dermis using either a fine needle or a cannula, depending on the area being treated.
The procedure typically takes around 10 minutes, though extra time is always allowed to ensure you feel relaxed and comfortable throughout. Once the injections are complete, the treated area is gently massaged with an antiseptic cream to ensure even distribution and optimal skin recovery.